I've killed several deer w/my .22 when I was younger and not one of them got away. Was it responsible to do so? No. But the point is, it doesn't take a 50cal to kill a yote. Its all about shot placement and shot selection. That being said, if I was buying a gun to hunt them w/I would buy a 220 swift or 22-250 instead of a 22but by no means is that the only thing that will kill them.