The 22-250 has more expensive shells than the 223, it will do a bit more fur damage to foxes, but usually not to serious except once in a while, but the bullet doesnt drop as fast as the 223, butthe 223 will still knock em down as far as you can accurately shoot without just guessing, so if you are shooting long range the 22-250 is the best unless price is an issue then 223 will still do the job.