If you simply want the very best, its the S&W 460. There's not another revolver out there that can match its speed or its versitility. It will shoot all of the 460 rounds, 454 casuls, and also 45 longs. Bigcountry is on the markon how accurate they are. I've only been shooting mine for a while and I can't believe the accuracy and the groups that I can shoot.(and I'm not a very good shot) Whatever handgun you use, I recommend aBurris scope with posi lock, to handle the recoil. Good Luck!