Fox are a very tough animal to judge what to shoot with because they are fast running, light skinned, and once you take the fur hes not a great deal bigger than a jack rabbit. ive seen numerous fox that were shot with every intention of beeing skinned and sold and they were killed by a 22-250 and had great big wholes in them, then again youve just got to break out the needle and thread. in my opinion as long as they arent 'hot' reloads any thing from a 220 swift to a 17 will get the job done.