The range is really close and I'm assuming you would have a good rest. I have to agree with the head shot and even a good neck shot will put them down. A lung shot will result in the coyote running off. He will eventually die but a little too slowly for a humane kill. Use something hot like a CCI Mini Mag or even a CCI Stinger and don't pull the trigger unless you have a "perfect" head shot on a motionless coyote. In the back yard, OK but don't hunt with a .22 LR.