Well, for the benefit of those that may be ballistic challenged, I have compiled some ballistic data by way of www.hornady.com and the ballistic calculator they provide.

I've listed ballistics for roundball, conical and sabot projectiles in 45, 50 cal and added comparisons to cartridge guns in 3030, 444 Marlin and 4570 Gvt. Data is listed for drop from a 100 yard zero at 200 and 300 yards and energy at the same distances.

.45 cal RB 200yd 300yd
Drop -25” -96” @ 2000fps
Energy 217# 145#

.45 cal
GreatPlains
285 grain
Drop -26” -87” @1400 fps
Energy 593# 483#

.50 cal RB
Drop -24.8” -93” @2000 fps
Energy 283# 191#

.50 cal
GreatPlains
385 grain
Drop -26.7” -90.6” @1400 fps
Energy 772# 624#

.50 cal
GreatPlains
410 grain
Drop -23.9” -80.3” @1400 fps
Energy 954# 791#

50cal
W/44cal
240grainXTP
Drop -10” -37” @2000fps
Energy 1126# 824#

50cal
W/44cal
300grXTP
Drop -10.6” -38” @2000fps
Energy 1398# 1012#

30-30
170 grain
Drop -9.4” -35.7” @2200 fps
Energy 793# 530#

444Marlin
265grain
flatpoint
Drop -8.2” -31.3” @2325fps
Energy 1400# 921#

4570Gvt
300gr
HP
Drop -10.4” -38.6” @2100fps
Energy 1313# 901#

As shown the round ball and conical have very close trajectories. The sabot/pistol bullet loads and older cartridge calibers listed are likewise very similar in trajectory. The program would not give me data for 3006 with a 100 yard zero so I am not showing data for that round.