alot of guns will do it with a well placed shot...if your good u can head shoot and not waste any meat..but thats a pretty small target...anything from a 243 on up will kill a deer with power to spare...i personally like the 3006..hits em like a train! i havent had a good lung hit deer make it over 25 yds...most drop where they stand...but im not one to worry about a few pounds of meat me and my dad both use 3006s and both like explosive bullets like a nosler ballistic tip or a good hollow point...hunting close range like we do and having guys that would probally shoot a deer if it ran by them even fatally wounded we like the extra shock and such the more explosive bullets give...and even at under 50yds the holes arent that big...