You might be able to get 2625fps ish with a stiff load of R-19. With 2" high at 100yds you'd be 0 at 200 and 8" low at 300yds. That would be fine for deer, but lighter bullets with good BC's would give you just as flat if not flatter trajectory to 300yds. I also wonder if the charge would fill the case too much and risk a COL problem. Those Bergers are LONG! Make sure your twist is close to a 10 as this is what Berger recommends. Hope this helps, Brett