Markeklund_ are you comfortable with shooting larger calibers?
Depending on what your stature isand shooting experience are you may do well with the '06. Many factory ammo offerings and can kill anything that walks in No. America.
Will this be your only rifle for a while, or are you planning on buying others in the near future? If you are, a solid two gun battery would be a .243 Win, .260 Rem, .270 Win for deer/antelope size game and a 7mm Mag or .300 WSM for the big stuff.Put a decent scope on them and hunt away!!!