ORIGINAL: Buckeye!
For anything from WhiteTail to Grizzly,53gr.s of H335 under a 405Gr. Rem. Soft nose...1825fps. in my 22in. barrelled Marlin
Now, that's a good load. The exact same amount of IMR 3031 gives almost identical performance.
In my Ruger No. 1, 300 grain bullets don't shoot too well, but 350 and 400-grain ones do.