For best all around handgun,a revolver hands down. In caliber,a .44 mag is awful hard to beat.
If you want a optical sight,I would reccomend a red dot,non magnifing sight would likely be a great choice.
There iscurrently 3 major brands that stand above the crowd in this configuration. Ruger,s&w,and taurus,in this order(my personal preference is ruger).