The TSX is one bullet I have not personally tried yet. I used theoriginal Barnes X in the 95 gr. 6MM-284, and the 165 gr. .300 Win Mag. Both of these bullets gave at least 50% more penetration than just about anything I had used up to that point, and did so at the expense of a fairly small wound channel. Neither were very good killers on broadside rib shots - although in each instance the animal did finally die. The shot that really impressed me with these original Barnes X's was the straight on shot - end for end - bang/flop.
They tell me these new TSX bullets are constructed a little differently from the original Barnes X. I probably need to give them a try