My next bow will likely be lefty to accomodate my eye dominance. I'm ambidextrous to begin with, but I'm more natural shooting right-handed. I shoot my rifles (all right-handed models) primarily right-handed, but I practice and have made difficult shots with both hands in the field also.

I'll be making the switch in a year or so. My left eye is better than 20/20, and I have much better low-light vision on the left. I figure the switch will add 15-20 minutes of available shooting light onto each day (5-10 minutes at dusk and dawn), and that translates into several hours of prime-time low-light stand time over the course of a season, which is enough incentive to make the change.

I don't think it'll take more than a few hours of range time to get things in sync.