TUK I have taken quite a few deer with the 44 Mag and one Elk. Most of the shots have been under 100 yards. Most were taken with the 300 grain Hornady XTP. I shot one Mule deer at about 150 yards with the 5 inch Revolver but that was to far to shoot and I was lucky that it worked out well.. I was using open sights. Scoped handguns will handle that range if you practice a lot.