I bought my first .280 Rem. in 1963. It is a Model 725 Rem., and I still own it. I killed lots of deer with it, first with factory ammo, then with my own reloads later on. It is one great caliber. I then went on to the 7mm Mag for about 20 years, and now I am in love with my 7mm-08. The "Sevens" are great deer killers and most have excellent accuracy potential.
I also own a Ruger 77V in .280 that I never seriously worked up a load for, as I bought a Swift right after that. All in all, I guess I would have to say that the .280 is one of the best "all-around" calibers you could own.
That's my story, and I'm stickin' to it..............