I use 250gr class for deer sized game. Reason trajectory gain, seem to have slightly better terminal performance (talking copper jacketedbullets here only) and accuracy. For elk, moose or bear I will bend on the above for deeper penetration so 300 class and up.

I admit I am not as versed as many here with all the different bullets, I have tried but seem to come back to the stand bythat have worked well in my Ml's in the past.