It depends on a lot of factors, including overall cost you're willing to spend. But I like the .308 You can shoot a .308 all day, and shooting a long shot isn't a problem, as long as you're confident and comfortable with the gun setup. A couple years ago, I had to make the same decision as you. I chose the .308 for my wife, and am glad I did that. Like was said eariler, the last thing you want to do is start her off on something with too much recoil, and develop a flinch. IMO.. go for the .308