The Barnes MZ 250 shoots great out of my .50 caliber and is my best bullet out of that barrel. I tried the 175 gr. out of my .45 and couldn't get any grouping whatsoever. I am of the opinion that a .45 is best served with a heavier longer bullet whether it be a sabot or conical. Sectional density is the name of the game when you can't shoot at smokeless powder velocities.