James B excellent post (once agin) that has been my saying all along most focus on the big bang instead of the output.I have a .300 win mag and I cant see that my deer with it are any deader (is that a word) then with my .270,.243,45/70,6.5x.284,or my .338 win mag.Lets focus on shooting skills more and not the calibur!!! Any rifle IMO above a .243 in the hands of a good shooter will take his game efficient and humane.