The unfortunate situation with open sights is that one must compromise on the focus point. Even so, I would agree that the best "compromise" is the front sight. Targets are going to be out of focus, but this is more of a problem for the range that it is for game. With game you won't have any trouble getting the bead where you need it on the animal.

Like cayugad, I prefer an aim point top and center of the bead, however, I have found this gives me trouble when centering a bead in an aperture. Itjust feels more natural to center "everything". Again, this won't be much of a problem on game but one may find that the bead begins obscures targets at the range at the farther distances. Using targets like crosses or x's that extend well beyond the bead at those ranges (when sighting) will give a reference to center in, not unlike the centering the bead in the aperture.

Happy Hunting, Phil