Most of the bucks I've seen travel with the wind,that way they can see in front and smell from behind. The important thing is to scout their travel routes they are comfortable using. They'll follow these paths regardless of wind direction. The trick is staying scent -free and playing the wind. I try to set up 2-3 stands pre-season in anticipation of a variety of wind direction on these routes and then try to be downwind of the direction you expect them to be moving.