Last year was my frist time trying lock-ons on my "spooky deer" east Texas lease. I'm pulling them for this upcoming season and will be going back to climbers only for that region.
I guess having both is the best way to go, but the element of surprise is why I like the climber the most. They don't know what tree I'm in on any given day. The lock ons- well they get tipped off to my presence each time I re-use the stand and slowly but surely the sightings go down with each hunt.

If you pull your lock-ons each time you hunt than the advantage is a wash.

I also feel safer in my climbers as well.