RE: shot gun slugs
My reasoning for sighting in at 50 yrds with these lead slingers is 1st and foremost Gravity. Supersonic and Subsonic after approx 50yrds down range as Lightfield states it best - and then - Wind Drift.
I sight all my sluggers in 2" high at 50yrd (clean clean cool cool barrel). Then - go out to 100yrds on a calm dry day and maybe tweek scope elevation a bit - Thats it!
Now the biggy is compensating for shots at 25+ - yrds!
Only reason I sight in for 100yrds is 3-4 deer stands give me a prime opportunity out to 125+ yrds.
When you live in a Shotgun only state you get a little anal about this nit picky crap.
Alot of guys can't make a decent 75yrd shot with a 12 gauge slugger because they don't follow simple rules when setting up and shooting these Freekin Canons with a scope.