This si what the Maryland DNR has to say about it.
Handgun Regulations
Modern and muzzleloading handguns may be used to hunt upland game (except dove and woodcock) and forest game (except turkey), woodchuck, fox, coyote, opossum, nutria, fisher, skunk and raccoon. However, modern handguns may be used to hunt deer only in those counties where the use of a breech-loading rifle for deer hunting is permitted with the exception that modern handguns may be used to hunt deer throughout Frederick County. Any modern handgun used for deer hunting must have a barrel length of 6 inches or more and use ammunition which produces a muzzle energy of 700 foot-pounds or more. Muzzleloading handguns (both single shot and revolvers) may be used to hunt deer in all counties. Muzzleloading handguns used for deer hunting must be at least .40 caliber in size with a barrel length of at least 6 inches and use not less than 40 grains of black powder (or a black powder equivalent) and propel one all-lead, lead alloy or copper soft-nosed or expanding bullet or ball at a single discharge. Contact the Maryland State Police for information about handgun purchase, possession, transport and use in non-hunting activities.
So, if y ou hunt a county that permits it, you can use a semi-auto. As long as it has a 6" barrel, and produces at least 700 ft-lbs. But you will be hard pressed to get the 6" and 700 ft-lbs. I'm sure it can be done, but will probably be very expensive.Look at the Desert Eagle's and check their barrel length.I would say you would be better off with a 44 mag revolver.