I would choose the 270 or 280 way above either of the above mentioned but if I had to pick one of those, I would take the 7 Mag and trade it in on a 270.If I had to use one of those, I guess it would be the 257 W. However I would also pick the 25-06 over the Weatherby. I have spent my life hunting Mule deer. I would guess I have taken 250 or so in 49 years of mulie hunting.