Why are you shooting coyote? Should be your first question and that will determine which tool (Gun) you use. For 100 yards anything from 22 mag and up willquicklykill acoyote. I use a dedicated 223 with 55 grain hollowpointfor coyote, fox and other varmints effectivly out to 350 yards, past that my 308 comes out with 168 grain hollowpoint. I hunt them strictlyfor management, my club property is over run with fox, some coyote and other opossum and coons that kill the small game rabbit, squirrl, turkey chicks, quail, and the endangered delmarva fox squirrl, and the other 39 people in the club don't understand game management or just don't care. The first couple of years I hunted turkey on the property I called 1 coyote and lost count of foxes typically one at every location I called from. I guess the answer is whatever you want to use as long as it's humaine, if you want to sell the pelts usesmaller caliber's 17, 22mag,204, 222, 223, and 22-250, if you just want to kill without regard to the pelt use your deer gun, the practice will make you a better rifleman with your deer gun.