Ya, I wouldn't use the uber-small .000000009 caliber varmint gun to take down a yote. If you breathe to heavily, you might have a bullet sway...LOL. One thing that wasn't stated is shot placement with say a .17 HMR. Head shot only under 100 yards. If you are not a good shot to place that, go into the .20 caliber range, so vital shots can be the norm for you.