Flip a coin and which ever one wins the toss will do very well for the game you are talking about. Either one with the proper bullet and good shot placement has taken all North American game for many years. Both have plenty of power and available bullets to reach the vitals of NA's big game. Your job is to practice enough to put the bullet where it needs to be. The 270 has a bit less recoil. The 06 has a bigger selection of bullets.