RE: 45 LC rifle ?
i would do brown bears but everything else seems reasonable. yes and for larger animals go with a hardcast for better penetration, but deer and hogs the sp will for fine
if you are looking for more velocity with the same pressure look into using a hodgdon powder called lil'gun, i have been having good success in terms of velocity in my .357 mag, and since it is a rifle the slower burning powder will help.
propmahn
you can never have too many guns