I sight my guns in so that the bullet will rise no more than three inches above line of sight (cross hairs). So for a typical cartridge firing a stream lined bullet at 3000 fps this translates to about 2.5 inches high at 100 yards.
If you hold dead center of an 8" target (about the size of a deers lungs) you will simply hit the top half of that target at 100 yards, hit the center at about 225 yards and then hit the bottom half at 300 yards. Regardless of where the bullet hits a deers lungs it is still a quick fatal shot. Out to aproximately 300 yards there is no need to hold high or low since you are aiming at a target of 8 inches in diameter or larger.