Are you talking about elevation clicks, or a parallax setting? Most centerfires should be plenty flat enough that you wouldn't need to make any adjustments at 150 yards. And even with a slug gun you could just aim a little high. Both my slug gun and muzzle loader have a point blank range of 150 or a bit more if sighted in correctly.

Will they be pinpoint accurate at every range? No, but they don't need to be to hit a deer in the vitals at those ranges. As long as you don't have more than 3 inches of drop or rise out to that distance you should be able to aim center of mass and make a kill shot. That is why they call it point blank range. If anything you could aim a hair high or low if you needed to.

For target or varmint shooting I like a mil dot reticle myself.

Paul