175 grain Nosler Partition from a 280 Remington, leaves the barrel just shy of 2700 fps. took a doe (175 lb dressed) head on at the bottom of the white on the neck on a slight downward angle. Distance was 168 yds GPS'd. Bullet entered, hit the spine and destroyed it and traveled through the lungs, punched the diaphram and came to rest against the stomach and didn't break it, thank the lord...