Well I tried a deer this weekend with mine (remington polymertipped...don't know if they were their own BT or nosler's)...50 yards...good shot, no shoulder (yes of course I'm assuming my own marksman ship). My buddy was down the field line about 100 yards. Said he watched the thing trot off into the sunset (o.k. actually it was about half mile across a bean field). Needless to say I'm NOT using my 22-250 until I have a load I KNOW is gonna leave me to blame for any lost animal. I feel bad enough for this one since I'm to blame regardless of shot placement.