yes it will pass through and give great blood trails.my wife and I shoot the 243.she shoots the Winchester PSP 100 grain bullet.I shoot the Winchester PSP 80 grain. they both do a great job of pas thyr and blood trails.that is the only cal gun we use and have for the past 25 years or so. many ,many ,many deer has fallen from the two guns.
she has only have one we didn't get,(bad hit,she shot low and hit the leg at the knee)we saw it runoff and she couldn't get another shot.
I had one about 20 years ago that I lost,don't know where I hit,we trailed him for several hrs. saw hin several times(couldn't shoot him because of where we were).

two in 25 years is not to bad.

as for the cal. and bullet ; it is great little weapon.I don't think you will be disappointed.