I have a .270 Wby Mag and have taken two whitetails, three mule deer, one pronghorn and two elk with it. All the deer and elk were taken with a 150 gr Partition and the antelope with a 130 gr Ballistic Tip. The closest shot was 40 yds (whitetail) and the farthest, 325 yds (5pt bull elk). None required a second shot and seven of the eight animals never took another step. The eighth was recovered about 40 yds from where it was hit. This round is essentially a cross between the two rounds you're considering, so I hope this helps.

Good Dogwork and Good Hunting