I had that experience with one of my Redfield bases. The screw came loose and fell out. Redfield replaced the screw at N/C. I asked about putting a drop of LocTite 242(blue)on it. Redfield didn't recommend doing that.I haven't had anymore problem since replacing the screw.I would recommend making sure it's tight and checking it from time to time. I've used Redfield JR/SR bases for about 30 years and that was the only problem I ever had or remember having. Ruger Redhawk

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