I agree with cayugad the 50 cal is a great choice. I have taken 1 bull moose with a 50 cal inline and it worked JFL. I also know of number of others who have taken moose also with 50 cal inlines. Like mentioned you can tailor your load for the hunt with a 50 cal very easily and the bullets they are producing makes this task even easier these days. Plus the popularity of the 50 cal means more choices and availability to the shooter.

As far as the Ml you choose, that is entirely upto you.TC or Knight are great choices. If you can use smokeless powder in a ML up in AK you may want to consider the Savage ML 10II as well. It is a fine shooting rig both with smokeless and subs...but the benefits of using IMR4759 or similar rifle powder can not be argued. I have a few hunting buds who have gone this route and will say I am impressed with the Savage. The latest was a couple of days ago, 2 shots at 25 to zero and then he banged out a 1" 3 shot group at 100...this after only 5 shots with his new ML.