Dave,
Mike's advice to check with PrBullets is right on!
They make about the best bullets on the market and they really know their stuff. In fact.....if you give them a call, they can tell you exactly which bullet to use in your rifle. Take their recommendation on bullet & power charge to heart......odds are they have already fired it at least 100 times in their own guns.
Personally, I've been shooting their 350gr QT polymer-tipped bullet over 90gr of Hodgdon Triple 7 (2fg) in my Knight and it works great. Check this link out to see what it did on a recent boar hunt. The shot distance was about 10yds.......complete penetration (bullet impacted in the opposite shoulder), minimal meat damage, & zero distance to recovery.
http://community.webshots.com/album/39293886KUEdol
"Every moving thing that liveth, I give unto you as meat" (Gen 9:3)
Trust God..........but keep your powder dry!