I have shot several deer with slugs. Other than a large hole through them, the damage is always less than what I think it should be. It seems like the slugs just punch a hole in them. I see more damage from my rifle where the bullets expands and just tears stuff up. A big hole through the vitals is very effective. I have never had one run more than 30 yards. The blood trails are very impressive.

The farthest I have shot is around 130 yards. Just go to the range and find out what the trajectory is with your gun and slug combination.