Here's a load I like in my .300 Wby Sako:

168 gr. Barnes TSX
RL22 84grs.
Fed215M primer
Norma brass

If you choose to try this load remember to start out with less powder and work up. This is especially true if you substitute a different component. This is a maximum load in my rifle.

I've also hadvery good luck with IMR7828in my .300 Wby. Overall, ithas probably worked better than any other powder. H4831 is anotherone to consider.