Are you considering an Alaskan Bear hunt, Griz or Brown ever?
If so I'd keep the 338. If the is not a desire of yours, then the downgrade in caliber would allow a flatter shooting rifle.
Good Luck!
Greg
"Getting close to the game is the joy of Bowhunting for me, the harvest is a bonus."

Live 15 ft Python after eating a small Antelope!