Follow those same loads above out to your 500 yards. Now list the ME of each. 243 @ 500 yards= 924 ME. 280 @ 500 Yards= 1371 ME. From Nosler. 100 grain 243 and 150 grain 280. Both BT design. Anyway to my way of thinking 500 yards is to far to shoot at deer with either. I like to limit shots to about 250 yards. I might consider 300 if all conditions are near perfect.