There are a lots of factors that will affect terminal ballistics. To me as a hunter, terminal ballistics means geting the animal down humanely, in the shortest distance, and time! Some people may misconstrue this as "overkill!" But there are other reasons besides just a "humane kill," that dictate getting the game down fast!
So the three most important bullet factors are going to be weight, speed, and bullet type! With the right combinations, I think that the faster bullets will preform better! But I would rather have a 200 gr. bullet going 2600 FPS than an 80 gr. bullet going 6000 FPS, even if you could push one that fast! Both would be deadly! The first within 0-200 yards, the second in 0 yds. to miles!
Zee, as far as the blood pressure theory, I don't think that they could really tell any difference at all, from a lung shot, or heart shot! Blood pressure will be dropping instantly either way! And its not the blood pressure the brain needs anyway, its the O2! No flow, no pressure, no O2! Either shot is good, the lungs are a great target! Taking out the heart is just gravy!