I know there are cartridges out there that are capable of taking big game beyond 400 yds. I am not personally capable of doing it with what I have and my shooting ability. I do know people that probably cold take animals beyond that distance with no problem. It has been done, it will surely be done again. If someone is up to the task, as well as the cartridge is, I see no problem in it at all. Now if someone takes the shot, the animal doesn't fall, so they just keep on hunting, or some other scenario like that, thats where I start to have problems.