if saving pelts the 243 is too hard on them. a 22 250 will reach out there but barrel life isnt soo hot. i think a 223 would be plenty of gun. its capable of taking 300 yards shots it wont burn up a barrel and its will put a yote down easy.

this yote was shot with a 22 250 55gr softpoint at 70yards this is the exit wound its not too hard on pelts but the barrel life is a concern. the bullet entered just behind the sholder, it put him down hard.