I hunt with a 3006. It's a caliber that I can shoot comfortably over and over again.With the newer bullets and powders available, under 500 yards an animal won't tell if it's hit with anything more powerful.
They drop like bricks.Military used it for half a century, the caliber has been an accomplished animal killer for 100 years and considering that the cal is the most popular hunting cal according to ammo sales, in North America, no more words need to be added.The record speaks for itself.

depending on how far the shots might be i use either a 270 with 130 gr federal fusion rds or a .50 cal t/c renegade with prb. this season im leaning more towards the blackpowder

I love my Remington Model 700 with 270 cal.
I shoot WInchester Silver Tips 130 grain.

model 70 270 with 130 gr bullet does wonders

My favorite caliber of choice is my Ruger 25-06 with 115 grain handloads. Its very accurate shot a deer last saturday with it and it dropped right there.

12ga smoothbore slug with remington sluggers

I use a Browning BAR 30-06 with Federal Premium ammo with Nosler Partition bullets. This combination has knocked down in their tracks almost every deer I have shot with it. Only a couple have run and they only went 30 to 50 yards and didn't even get out of sight.

Nice thing about the partitions is they hold together and blow a nice hole clear through the deer. Leaves a nice blood trail though I haven't needed it. :)

I can't choose just one :rock:
Here are a few I like to use, .243, .260, .270, .280, 7mm-08, ,7mm Rem Mag, .270 WSM, .300WSM, 7RUM, 300RUM

Let me end the debate. They all kill them dead! LOL!

That brought back memories. And lots of laughs, wonder
if Buckmaster has changed his mind yet it's been 5 years, maybe he's changed his mind.Anybody know what happened to stubblejumper?

encore 25-06, 120 gr positive expansion. Blows a hole for a blood trail and shoots flat. Last year my son shot a good buck and buried under the hide in the off shoulder after blowing about 3 inches of bone out of the other shoulder. Went less than 20 yards. Truth is there is no best caliber for everyone. I like low recoil and a good trajectory but a lot of recoil won't bother the next guy so he can have the short mags if he wants them.