If all you had was a .243 shooting an 80 grain bullet on the last evening you can hunt and time is almost gone, with a leary buck standing broad side 300 yards away, would you take the shot? you have a steady rest in a deer blind.

1st day, middle of the season, or last day shouldnt have an effect on your shot ethics

as long as your practiced for a shot of that distance, the bullet is enough!

If you are confident in the shot, why not?

shot placement is the key

I agree with averyone on here go for it, I also shoot a .243 but I use a 90 grain remingtonballistic tips.

why wouldnt you?? i use a .243 and i use the same grain as you i make long shots like that all the time

Dead deer, don't even have to think about it.

I wouldn't take the shot because of two reasons:

[ol][*]Not comfortable with a shot of that distance, even with a more powerful rifle/bullet grain combo[*]In my opinion, that is aHIGHRISK SHOT. Too many variables to consider to make an ethical shot/ethical kill.[/ol]
That's my two cents worth.

Nope, because rifles are illegal to hunt deer with in IA