Since a chain is only as strong as its weakest link, my choice would be to start with the the caliber to hunt the biggest, most dangerous game and work down from there...my vote goes to the 300 Win Mag.

The 375 H&H hands down. For smaller game such as deer it can be loaded down with lighter bullets and can be used with confidence in dangerous situations on the great bears in North America.
If limited to only one rifle ,this would be my choice ,plus you ready for that African safari also.

tough choice, though i think i go with the 45colt. lots of versitily. though if i was true caliber then id choose 357 for an asorted range of calibers

it would have to be my .270 Win, possibly .300 Wby

slayer

.30-06 for sure....you could load it with some big bullets up to 220 grains I believe

If I were stuck in North America I would stay faithful to my 30-06. Since I want to hunt in Africa some day if I could only pick one, I' d also go with the .375 H&H.

.308 winchester only rifle i hunted with for 33 years see no reason to change

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7mm rem mag. for me.. takes all game quick and easy

One gun only for the rest of my life! Thats a tough one. I am going to have to go with my .450 Marlin all my shooting is in close and I have grizzlies in my neck of the woods so its a nice comforting feeling to have it on my shoulder! Its a bit much for a whitetail but just right for a nice big bear or moose!

Excellent question!