I'm picking up a .243 mainly for antelope.....probably a backup on a mule deer hunt, though may become my mule deer rifle.

I've used a .270 on antelope and the results were overkill, bullet's always blew right through them.

I've heard the .25-06 billed as the perfect antelope rifle, though I'm thinking a .243 may be perfect.

I think for that combo though, 25-06 or .270 would be about as ideal as they come, not overkill for either, nor undergunned either.

But anything from .243 to .30-06 would do both fine.

My 7mm Rem Mag absolutely made a mess out of the last antelope I shot. 140gr Nosler AccuBond loaded to max velocity did a number on the goat. Thought there mighta been 2 pieces when I walked up to it.....

I'll be shooting my 243 or my 25WSSM this fall for goats.

I've usedthe243 win and 25-06 Rem both on them and either one work great .

.25-06 people have been harvesting everything from yotes to elk with this caliber.

the .25-06 is my primary hunting rifle

I would go with a .25-06 if it were me.

25-06 then 243

.270 Win.

A 7-08 would be a good choice.