What would you use? Have you ever shot a buffalo? If so with what, and what was the result? 1 shot? What would your #1 choice be, and then what would your choice be to drop one at 300yds?

.338 Win mag, or 50 BMG

45-70

I have never hunted for Buffalo. But I hope to in the next couple of years. I imagine the modern magnums would be the best choice. But I could not see hunting with anything but a 45-70, or larger "antique" cartridge. The rifle should be a Sharp's or an 1886. Nostalgia I guess. Tom.

I was thinking 375 H&H but you said at 300 yards at the end of your post. Now imleaning towards a 338 Ultra Mag, 338 Laupua Mag, or 50 BMG.

I don't think you need to shoot one at 300 yds. I am also planning a bison hunt but still figuring where to go. Thousands have fallen to the 45-70 using a 405 gr lead bullet. I like the old timers too. But if its a modern chambering you want to use, I'd say the 300 mags or bigger. The owner of my gun shop went out and got one along with his friend. Both used a Sharps 45-70. They got a huge pile of steaks and roasts and 9 - 5 gal buckets of burger. Geez that's a lot of meat.

7RM & 140TSX

375 H&H

I was going to go and was planning on using my .450 Marlin. You don't need to make over a 200 yard shot. Any good heavy caliber will work though most people seem to like to use the 45/70 because of tradition.

Yeah it is a tradition but that old 45/70 with modern powder will flatten a buffalo.I couldnt think of a better round.Buffalo Bore or Garrett rounds are awesome just make sure it is a modern firearm capable of handling those rounds.